Mixing productive economic activities with housing is a hot topic in academic and policy discourses on the redevelopmentof large cities today. Mixed‐use is proposed to reduce adverse effects of modernist planning such as single‐use zoning,traffic congestion, and loss of quality in public space. Moreover, productive city discourses plead for the re‐integration ofindustry and manufacturing in the urban tissue. Often, historical examples of successful mixed‐use in urban areas serveas a guiding image, with vertical symbiosis appearing as the holy grail of the live‐work mix‐discourse. This article examinesthree recent live‐work mix projects developed by a public real estate agency in Brussels. We investigate how differentspatial layouts shape the links between productive, residential, and other land uses and how potential conflicts betweenresidents and economic actors are mediated. We develop a theoretical framework based on earlier conceptualisations ofmixed‐use development to analyse the spatial and functional relationships within the projects. We situate them within thehousing and productive city policies in Brussels. From this analysis, we conclude that mixed‐use should be understood byconsidering spatial and functional relationships at various scales and by studying the actual spatial layout of shared spaces,logistics and nuisance mitigation. Mixed‐use is highly contextual, depending on the characteristics of the area as well aspolicy goals. The vertical symbiosis between different land uses is but one example of valid mixed‐use strategies along with good neighbourship, overlap, and tolerance. As such, future commercial and industrial areas will occur in various degreesof mixity in our cities.