This report consists of two parts. The first part is an exploration of the spatial conditions for the transition to a circular economy (CE) in Flanders and the implications for the spatial use of companies: what are the spatial challenges and opportunities that influence the circular economy in Flanders? On which type of environments does the CE have the most influence? The starting point for this are the 6 strategic of Circular Flanders on bioeconomy, circular construction, manufacturing, chemistry & plastics, water loops and the food chain. The second part of this report contains an research by design study, starting from concrete cases of circular companies that can serve as a model for other circular initiatives in Flanders: what are the operational models, challenges and success factors? What are the preconditions for extrapolation and scaling up on the scale of Flanders? What should we take into account with regard to the spatial organisation of the CE in Flanders? The study concludes that Flanders has the ambition to become an important Circular Hub within Europe. However, there is a need for a clear outline and translation of this ambition into different spatial scenarios and their consequences on spatial policies. It is important to map out the problems and the limiting factors in more detail. It may be necessary to make choices about which circular sectors are given priority within our context of a space-efficient policy (cf. the construction shift). Clear choices will have to be made and this in different spatial contexts such as the preservation of and mixing economic sites in the city, the optimization of spatial efficiency in economic sites, and the use of temporarily available space.